April 3, 2025

Medical Coding Sepsis

By Janine Mothershed

Guidelines and Tips for Coding and Billing Sepsis & Septic Shock

Sepsis and septic shock are serious medical conditions that require prompt diagnosis and treatment. Proper coding and billing for sepsis and septic shock are crucial for ensuring accurate reimbursement and compliance with healthcare regulations. Medical coders must be meticulous when coding these conditions because they have specific guidelines that must be followed to ensure accurate claims submission.

In this blog, we’ll explore the guidelines for coding sepsis and septic shock, common mistakes to avoid, and helpful tips for accurate coding and billing.

Understanding Sepsis and Septic Shock

Before diving into coding and billing, it’s essential to understand what sepsis and septic shock are:

  • Sepsis: Sepsis is a life-threatening condition that occurs when the body’s response to infection leads to widespread inflammation, tissue damage, and organ dysfunction. It can occur in response to infections such as pneumonia, urinary tract infections (UTIs), or abdominal infections.

  • Septic Shock: Septic shock is a severe form of sepsis that results in a significant drop in blood pressure, leading to organ failure and an increased risk of death. It is a medical emergency that requires immediate intervention.

Sepsis and Septic Shock Coding Guidelines

Coding sepsis and septic shock requires an understanding of the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes, and how they are used to describe these conditions accurately.

Sepsis Coding Guidelines:

Sepsis codes in ICD-10-CM fall under A40A41 and represent different types of infections that can lead to sepsis. The selection of the correct code depends on the infection site, organism causing the infection, and the patient’s specific condition.

  • A40 – Streptococcal sepsis

  • A41 – Other sepsis (which includes a variety of causes such as Gram-negative organisms or sepsis of unknown origin)

Here are some key guidelines to follow:

  • Document the Causative Organism: When sepsis is caused by a specific pathogen, the organism must be documented. For example, A40.0 (Group A streptococcal sepsis) or A41.51 (Sepsis due to Escherichia coli [E. coli]).

  • Sepsis Documentation: If the sepsis is not clearly caused by a specific pathogen, the appropriate A41.9 code (Sepsis, unspecified organism) should be used.

  • Sepsis is Often Accompanied by Organ Dysfunction: For sepsis with organ dysfunction (like renal failure, respiratory failure, etc.), the specific organ failure codes should be listed as secondary diagnoses. For example, N17 for acute kidney failure or J96 for respiratory failure.

Septic Shock Coding Guidelines:

Septic shock is classified separately in ICD-10-CM, and it’s critical to use the correct code for billing purposes.

  • R65.21 – Severe sepsis with septic shock: This code is used when septic shock is identified in the presence of severe sepsis, which includes organ failure or dysfunction.

  • Severe Sepsis: Severe sepsis refers to sepsis with signs of organ dysfunction or inadequate perfusion, including hypotension (low blood pressure), respiratory failure, renal failure, or liver dysfunction. When both severe sepsis and septic shock are documented, R65.21 should be used along with codes for the specific organ dysfunctions.

  • Septic Shock and Organ Dysfunction: If septic shock is accompanied by specific organ failure, codes for the organ dysfunction (e.g., N17 for acute kidney failure) should be included as secondary diagnoses.

Key Documentation Tips for Sepsis and Septic Shock Coding

Accurate coding starts with proper documentation. Here are some tips to ensure that sepsis and septic shock are documented thoroughly:

  • Clearly Indicate Sepsis and Septic Shock: The medical record should explicitly state that the patient has sepsis or septic shock. Simply listing “infection” or “bacteremia” may not be sufficient, as these terms do not necessarily imply sepsis or septic shock.

  • Identify the Source of Infection: Sepsis coding requires documenting the source of the infection, such as a respiratory infection, urinary tract infection, or abdominal infection. Knowing the infection’s site helps with accurate coding.

  • Note Organ Dysfunction: Sepsis often leads to organ dysfunction. If organ dysfunction is present (e.g., acute renal failure, respiratory failure, or cardiovascular collapse), the healthcare provider should document the specific dysfunctions so coders can assign the appropriate codes.

  • Document the Causative Organism: Whenever possible, document the pathogen or microorganism responsible for the infection, such as a specific bacterium or virus (e.g., A41.51 for Escherichia coli sepsis).

  • Include Severe Sepsis and Septic Shock Diagnosis: If both severe sepsis and septic shock are documented, R65.21 (Severe sepsis with septic shock) should be coded. Be sure to include all organ dysfunctions.

Common Mistakes in Sepsis and Septic Shock Coding

While sepsis and septic shock coding may seem straightforward, there are several common pitfalls to avoid:

  • Incorrect Use of Sepsis Codes: Sepsis and septic shock are two distinct conditions, and it’s important to code them separately. Use A41.9 (Sepsis, unspecified organism) when the organism is not identified and R65.21 for septic shock.

  • Not Documenting Organ Dysfunction: Sepsis often causes organ dysfunction, and failing to document the specific organ failure can result in incomplete coding. Ensure that all associated organ failures are properly documented.

  • Misunderstanding of Severe Sepsis vs. Septic Shock: Severe sepsis refers to sepsis with organ dysfunction, whereas septic shock specifically involves a drop in blood pressure leading to organ failure. It’s important to differentiate between these two when coding.

  • Failure to Report Underlying Infection: If a specific infection (e.g., pneumonia, UTI, etc.) is the cause of sepsis, it should be documented clearly and coded appropriately. Do not simply code sepsis without documenting the underlying infection.

Sepsis and Septic Shock Billing Tips

Once the proper codes are assigned, there are additional billing considerations to keep in mind:

  • Accurate Documentation: Ensure that all medical documentation supports the codes you are submitting. Inaccurate or incomplete documentation can lead to claim denials or audits.

  • Billing for Sepsis-Related Services: Sepsis and septic shock often require extensive treatment, including laboratory tests, imaging, and ICU care. Ensure that all services provided are appropriately documented and coded.

  • Modifiers: Use appropriate modifiers when necessary to indicate additional procedures or services provided during the treatment of sepsis and septic shock, such as modifier 25 for an E/M service performed on the same day as a procedure.

  • Preventive and Post-Discharge Care: Sepsis can have long-term health impacts. If the patient requires ongoing treatment or follow-up care after discharge, ensure that these services are correctly coded and billed.

Important Considerations for Sepsis and Septic Shock Billing

  • Payer Policies: Different payers may have specific guidelines for sepsis and septic shock billing, so always check the payer’s policies before submitting a claim.

  • Coding for Comorbidities: If the patient has comorbid conditions that complicate their sepsis (e.g., diabetes or immunocompromised state), make sure these conditions are documented and coded appropriately as secondary diagnoses.

  • Complications of Sepsis: Sepsis can lead to complications such as acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), and multi-organ failure. These complications should be coded as secondary diagnoses.

Accurate coding and billing for sepsis and septic shock are critical for ensuring proper reimbursement and compliance with medical regulations. Coders should follow ICD-10-CM guidelines carefully, ensuring all relevant documentation is included, and correctly identifying the causative organism, organ dysfunctions, and other complicating factors. By following these guidelines and using the appropriate codes for sepsis and septic shock, healthcare providers can help ensure accurate claims submission and reduce the risk of audits or denials.

CMS https://www.cms.gov/icd10manual/version33-fullcode-cms/fullcode_cms/P0328.html

Coding Clarified Blog https://codingclarified.com/medical-coding-blog/

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